This project has advanced from a Year 6 Great Lakes Comprehensive Center (GLCC) project focusing on literacy, Indiana PreK–12 Literacy Framework, into a statewide model for multi-tiered systems of support (MTSS). In Year 6, the Indiana Department of Education (IDOE) literacy team developed the Indiana PreK–12 Literacy Framework to help educators provide quality literacy instruction. IDOE also convened a cross-agency team to develop a statewide model for MTSS to address academic, behavioral, and social-emotional needs in schools. MTSS is part of the Indiana Every Student Succeeds Act (ESSA) plan, and also part of the IDOE strategic plan. In Year 7, GLCC will provide content expertise, relationship brokering, coaching, and thought partnering to increase IDOE’s capacity to support local education agencies (LEAs) in their use of the MTSS model and to support the refinement and implementation of the Indiana PreK–12 Literacy Framework. GLCC will specifically provide this support to the six-school year-long pilot that starts with the opening of the 2018-19 school year. This project will increase IDOE’s capacity to lead and collaborate with Indiana school districts, educators, higher education institutions, and stakeholders regarding the literacy framework.